Lozano C, Torres JL, Julia L, Jimenez A, Centelles JJ, Cascante M. Effect of new antioxidant cysteinyl-flavanol conjugates on skin cancer cells. FEBS Lett. 2005 Aug 15;579(20):4219-25

 

Frederiks WM, van Marle J, van Oven C, Comin-Anduix B, Cascante M. Improved Localization of Glucose-6-Phosphate Dehydrogenase Activity in Cells with 5-Cyano-2,3-ditolyl-tetrazolium Chloride as Fluorescent Redox Dye Reveals Its Cell Cycle-dependent Regulation. J Histochem Cytochem. 2005 Jan;54 (1):47-52

 

Selivanov VA, Meshalkina LE, Solovjeva ON, Kuchel PW, Ramos-Montoya A, Kochetov GA, Lee PW, Cascante M. Rapid simulation and analysis of isotopomer distributions using constraints based on enzyme mechanisms: an example from HT29 cancer cells. Bioinformatics. 2005 Sep 1;21 (17):3558-64

Vizan P, Boros LG, Figueras A, Capella G, Mangues R, Bassilian S, Lim S, Lee WN, Cascante M. K-ras codon-specific mutations produce distinctive metabolic phenotypes in mice [corrected] fibroblasts. Cancer Res. 2005 Jul 1;65(13):5512-5.

Tourino S, Selga A, Jimenez A, Julia L, Lozano C, Lizarraga D, Cascante M, Torres JL.  Procyanidin fractions from pine (Pinus pinaster) bark: radical scavenging power in solution, antioxidant activity in emulsion, and antiproliferative effect in melanoma cells. J Agric Food Chem. 2005 Jun 15;53(12):4728-35.

Amaia A, Pachon G, Cascante M, Creppy EE, Monge A, Lopez de Cerain A. Selective toxicity of a quinoxaline 1,4-di-N-oxide derivative in human tumour cell lines. Arzneimittel-Forsch. 2005;55(3):177-82.

Azqueta A, Pachon G, Cascante M, Creppy EE, Lopez de Cerain A. DNA damage induced by a quinoxaline 1,4-di-N-oxide derivative (hypoxic selective agent) in Caco-2 cells evaluated by the comet assay. Mutagenesis. 2005 May;20(3):165-71. Epub 2005 Apr 7.

Lee WN, Guo P, Lim S, Bassilian S, Lee ST, Boren J, Cascante M, Go VL, Boros LG. Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment.Br J Cancer. 2004 Dec 13;91(12):2094-100.

Boros LG, Serkova NJ, Cascante M, Lee WNP. Use of metabolic pathway flux information in targeted cancer drug design. Drug Discov Today: Ther Strateg 2004 1(4):435-443

Goldstein BN, Ermakov G, Centelles JJ, Westerhoff HV, Cascante M. What makes biochemical networks tick? Eur J Biochem. 2004 Oct;271(19):3877-87.

Vitaly A. Selivanov, Joaquim Puigjaner, Antonio Sillero, Josep J. Centelles, Antonio Ramos-Montoya, Paul WN Lee and Marta Cascante. An Optimized Algorithm for Flux Estimation from Isotopomer Distribution in Glucose Metabolites. Bioinformatics 2004 Dec 12;20(18):3387-97. Epub 2004 Jul 15.(Program free download).

Marin S, Lee WN, Bassilian S, Lim S, Boros LG, Centelles JJ, Fernandez-Novell JM, Guinovart JJ, Cascante M. Dynamic profiling of the glucose metabolic network in fasted rat hepatocytes using [1,2- 13C 2]-glucose. Biochem J. 2004  Jul 1;381(Pt 1):287-94.

Marin S, Chiang K, Bassilian S, Lee WN, Boros LG, Fernandez-Novell JM, Centelles JJ, Medrano A, Rodriguez-Gil JE, Cascante M. Metabolic strategy of boar spermatozoa revealed by a metabolomic characterization. FEBS Lett. 2003 Nov 20;554(3):342-6.

Maher AD, Kuchel PW, Ortega F, de Atauri P, Centelles J, Cascante M. Mathematical modelling of the urea cycle. A numerical investigation into substrate channelling. Eur J Biochem. 2003 Oct;270(19):3953-61.

Orosz F, Wagner G, Ortega F, Cascante M, Ovadi J. Glucose conversion by multiple pathways in brain extract: theoretical and experimental analysis. Biochem Biophys Res Commun. 2003 Oct 3;309(4):792-7.

Sakamoto N, de Atauri P, Cascante M. Characterization of the transit and transition times for a pathway unit of Michaelis-Menten mechanism. Biochim Biophys Acta. 2003 Sep 8;1623(1):6-12.

Boros LG, Steinkamp MP, Fleming JC, Lee WN, Cascante M, Neufeld EJ. Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA). Blood. 2003 Nov 15;102(10):3556-61. Epub 2003 Jul 31.

Vera J, de Atauri P, Cascante M, Torres NV. Multicriteria optimization of biochemical systems by linear programming: application to production of ethanol by Saccharomyces cerevisiae. Biotechnol Bioeng. 2003 Aug 5;83(3):335-43

Boren J, Lee WN, Bassilian S, Centelles JJ, Lim S, Ahmed S, Boros LG, Cascante M. The stable isotope-based dynamic metabolic profile (SIDMAP) of butyrate induced HT29 cell differentiation.  J Biol Chem. 2003 Aug 1;278(31):28395-402. Epub 2003 May 15.

Matito C, Foteini M, Centelles J.J, Torres J.L. and Cascante. Antiproliferative effect of antioxidant polyphenols from grape in murine Hepa-1c1c7. Eur J Nutr 2003, 42: 43-49.

 

Creppy EE, Traore A, Baudrimont I, Cascante M and Carratu MR. Recent advances in the study of epigenetic effects induced by the phycotoxin okadaic acid. Toxicology 2002 Dec 27;181-182:433-9.

	Torres JL, Varela B, García MT, Carilla J, Matito C, Centelles JJ, Cascante M, Sort X and Bobet R. Valorization of grape (Vitis vinifera) byproducts. Antioxidant and biological properties of polyphenolic fractions differing in procyanidin composition and flavonol content. J Agric Food Chem. 2002 Dec 18;50(26):7548-55.
	Lozano C, Cascante M, Torres JL. Cation-exchange micropreparative separation of galloylated and non-galloylated sulphur conjugated catechins. J Chromatogr A. 2002 Oct 11;973(1-2):229-34.

 

Comin-Anduix B, Boros LG, Marin S, Boren J, Callol-Massot C, Centelles JJ, Torres JL, Agell N, Bassilian S, Cascante M.  Fermented Wheat Germ Extract Inhibits Glycolysis/Pentose Cycle Enzymes and Induces Apoptosis through Poly(ADP-ribose) Polymerase Activation in Jurkat T-cell Leukemia Tumor Cells. J Biol Chem. 2002 Nov 29;277(48):46408-46414.

Boren J, Montoya AR, de Atauri P, Comin-Anduix B, Cortes A, Centelles JJ, Frederiks WM, Van Noorden CJ, Cascante M. Metabolic control analysis aimed at the ribose synthesis pathways of tumor cells: a new strategy for antitumor drug development. Mol Biol Rep. 2002;29(1-2):7-12.

 

Ortega F, Ehrenberg M, Acerenza L, Westerhoff HV, Mas F, Cascante M. Sensitivity analysis of metabolic cascades catalyzed by bifunctional enzymes. Mol Biol Rep. 2002;29(1-2):211-5.

 

Cardenas ML, Ortega F, Cascante M, Cornish-Bowden A. Modulation of metabolite concentrations with no net effect on fluxes. Mol Biol Rep. 2002;29(1-2):17-20.

 

Boros LG, Lee WN, Cascante M. Imatinib and chronic-phase leukemias. N Engl J Med. 2002 Jul 4;347(1):67-8.

 

Torres JL, Lozano C, Julia L, Sanchez-Baeza FJ, Anglada JM, Centelles JJ, Cascante M. Cysteinyl-flavan-3-ol conjugates from grape procyanidins. Antioxidant and antiproliferative properties. Bioorg Med Chem. 2002 Aug;10(8):2497-509.

 

Agius L, Centelles J, Cascante M. Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways? Biochem Soc Trans. 2002 Apr;30(2):38-43.

 

De Atauri P, Fell DA, Chassagnole C, Magret D, Mazat JP, Cascante M. Dependence of control coefficient distribution on the boundaries of a metabolic system: a generalized analysis of the effects of additional input and output reactions to a linear pathway.  Journal of Theoretical Biology, 2002;215:239-251.

 

Repiso A, Boren J, Ortega F, Pujades A, Centelles J, Vives-Corrons JL, Climent F, Cascante M y Carreras J. Triosephosphate isomerase deficiency. genetic, enzymatic and metabolic characterization of a new case from Spain. Haematologica 2002 Apr;87(4):ECR12.

 

Cascante M, Boros LG, Comín-Anduix B, De Atauri P, Centelles JJ, Lee PW-N. Metabolic control analysis in drug discovery and disease.  Nature Biotechnology, 2002;20:243-249.

 

Ortega F, Acerenza L, Westerhoff HV, Mas F, Cascante M. Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades.  Proceedings of National Academic of Sciences U.S.A. 99, 1170-1175 (2002).

 

Boros LG, Cascante M, Lee W-NP. Metabolic profiling of cell growth and death in cancer: applications in drug discovery.  Drug Discovery Today 2002;7:364-371.

 

Comín-Anduix B, Agell N, Bachs O, Ovádi J, Cascante M. A New Bis-Indole, KARs, Induces Selective M Arrest with Specific Spindle Aberration in Neuroblastoma Cell Line SH-SY5Y. Molecular Pharmacology. 2001;60(6):1235-1242.

 

Boren J, Cascante M, Marín S, Comín-Anduix B, Centelles JJ, Lim S, Bassilian S, Ahmed S, Lee W-NP, Boros LG. Gleevec (STI571) Influences Metabolic Enzyme Activities and Glucose Carbon Flow toward Nucleic Acid and Fatty Acid Synthesis in Myeloid Tumor Cells. The Journal of Biological Chemistry. 2001;276(41):37747-377532001.

 

Cortés A, Cascante M, Cárdenas ML, Cornish-Bowden A. Relationships between inhibition constants, inhibitor concentrations for 50% inhibition and types of inhibition: new ways of analysing data. Biochemical Journal 2001;357:263-268.

 

Boros LG, Lapis K, Szende B, Tömösközi-Farkas R, Balogh A, Boren J, Marin S, Cascante M, Hidvégi M. Wheat Germ Extract Decreases Glucose Uptake and RNA Ribose Formation but Increases Fatty Acid Synthesis in MIA Pancreatic Adenocarcinoma Cells. Pancreas 2001;23(2):141-147.

 

Comín-Anduix B, Boren J, Martinez S, Moro C, Centelles JJ, Trebukhina R, Petushok N, Lee W-PL, Boros LG, Cascante M. The effect of thiamine supplementation on tumour proliferation: A metabolic control analysis study. European Journal of Biochemistry 2001;268:4177-4182.

 

De Atauri P, Acerenza L, Kholodenko BN, De la Iglesia N, Guinovart JJ, Agius L, Cascante M. Occurrence of paradoxical or sustained control by an enzyme when overexpressed: necessary conditions and experimental evidence in the case of hepatic glucokinase. Biochemical Journal  2001;355:787–793.

 

Ruggia A, Gelpi JL, Busquets M, Cascante M, Cortes A. Effect of several anions on the activity of mitochondrial malate dehydrogenase from pig heart. J Mol Catal B-Enzym 2001;11(4-6):743-755 Sp. Iss.

2006-...