Santos RC, Salvador JA, Cortés R, Pachón G, Marín S, Cascante M. New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells. Biochimie. 2011 Mar 3. [Epub ahead of print]

Maier D, Kalus W, Wolff M, Kalko SG, Roca J, Marin de Mas I, Turan N, Cascante M, Falciani F, Hernandez M, Villa-Freixa J, Losko S. Knowledge management for Systems Biology a general and visually driven framework applied to translational medicine. BMC Syst Biol. 2011 Mar 5;5(1):38. [Epub ahead of print].

Ramírez-Bajo MJ, Repiso A, la Ossa PP, Bañón-Maneus E, de Atauri P, Climent F, Corrons JL, Cascante M, Carreras J. Enzymatic and metabolic characterization of the phosphoglycerate kinase deficiency associated with chronic hemolytic anemia caused by the PGK-Barcelona mutation. Blood Cells Mol Dis. 2011 Mar 15;46(3):206-11.

	Pastor I, Vilaseca E, Madurga S, Garcés JL, Cascante M, Mas F. Effect of crowding by dextrans on the hydrolysis of N-Succinyl-L-phenyl-Ala-p-nitroanilide catalyzed by α-chymotrypsin. J Phys Chem B. 2011 Feb 10;115(5):1115-21.
	de Atauri P, Benito A, Vizán P, Zanuy M, Mangues R, Marín S, Cascante M. Carbon metabolism and the sign of control coefficients in metabolic adaptations underlying K-ras transformation. Biochim Biophys Acta. 2010 Dec 23. [Epub ahead of print]

Selivanov VA, Vizán P, Mollinedo F, Fan TW, Lee PW, Cascante M. Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis. BMC Syst Biol 2010 Oct 6;4:135.

Cascante M, Benito A, Zanuy M, Vizán P, Marín S, de Atauri P. Metabolic network adaptations in cancer as targets for novel therapies. Biochem Soc Trans. 2010 Oct;38(5):1302-6.

Rodríguez-Prados JC, Través PG, Cuenca J, Rico D, Aragonés J, Martín-Sanz P, Cascante M, Boscá L. Substrate Fate in Activated Macrophages: A Comparison Between Innate, Classic, and Alternative Activation. J Immunol. 2010 Jul 1;185(1):605-614.

Santos RC, Salvador JA, Marín S, Cascante M, Moreira JN, Dinis TC. Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid. Bioorg Med Chem. 2010 Jun 15;18(12):4385-4396.

Lavaggi ML, Cabrera M, Aravena MD, Olea-Azar C, López de Ceráin A, Monge A, Pachón G, Cascante M, Bruno AM, Pietrasanta LI, González M, Cerecetto H. Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation.Bioorg Med Chem. 2010 Jun 15;18(12):4433-4440.

Alcarraz-Vizán G, Boren J, Lee W-N.P, Cascante M. Histone deacetylase inhibition results in a common metabolic profile associated with HT29 differentiation. Metabolomics 2010 Jun;6(2):229-237.

Pastor I, Vilaseca E, Madurga S, Garcés JL, Cascante M, Mas F. Diffusion of alpha-chymotrypsin in solution-crowded media. A fluorescence recovery after photobleaching study. J Phys Chem B. 2010 Mar 25;114(11):4028-34.

Selivanov VA, Votyakova TV, Zeak JA, Trucco M, Roca J, Cascante M. Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia. PLoS Comput Biol. 2009 Dec;5(12):e1000619.

Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE Jr, Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res. 2010 Jan 1;70(1):12-3.

Touriño S, Fuguet E, Vinardell MP, Cascante M, Torres JL. Phenolic metabolites of grape antioxidant dietary fiber in rat urine. J Agric Food Chem. 2009 Dec 9;57(23):11418-26.

Pachón-Peña G, Reyes-Zurita FJ, Deffieux G, Azqueta A, de Cerain AL, Centelles JJ, Creppy EE, Cascante M. Antiproliferative effect of flavomannin-6,6'-dimethylether from Tricholoma equestre on Caco-2 cells. Toxicology. 2009 Oct 29;264(3):192-7.

Santos RC, Salvador JA, Marín S, Cascante M. Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity. Bioorg Med Chem. 2009 Sep 1;17(17):6241-6250.

Vizán P, Sánchez-Tena S, Alcarraz-Vizán G, Soler M, Messeguer R, Pujol MD, Paul Lee WN, Cascante M. Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets. Carcinogenesis. 2009 Jun;30(6):946-952.

Vizán P, Alcarraz-Vizán G, Díaz-Moralli S, Solovjeva ON, Frederiks WM, Cascante M.  Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29. Int J Cancer. 2009 Jan 15;124(12):2789-96.

Rodríguez-Prados JC, de Atauri P, Maury J, Ortega F, Portais JC, Chassagnole C, Acerenza L, Lindley ND, Cascante M. In silico strategy to rationally engineer metabolite production: A case study for threonine in Escherichia coli. Biotechnol Bioeng. 2009 Jan 20;103(3):609-620.

Lizárraga D, Touriño S, Reyes-Zurita FJ, de Kok TM, van Delft JH, Maas LM, Briedé JJ, Centelles JJ, Torres JL, Cascante M. Witch hazel (Hamamelis virginiana) fractions and the importance of gallate moieties--electron transfer capacities in their antitumoral properties. J Agric Food Chem. 2008 Dec 24;56(24):11675-82.

Touriño S, Fuguet E, Jáuregui O, Saura-Calixto F, Cascante M, Torres JL. High-resolution liquid chromatography/electrospray ionization time-of-flight mass spectrometry combined with liquid chromatography/electrospray ionization tandem mass spectrometry to identify polyphenols from grape antioxidant dietary fiber. Rapid Commun Mass Spectrom. 2008 Nov;22(22):3489-500.

Reyes-Zurita FJ, Rufino-Palomares EE, Lupiáñez JA, Cascante M. Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway. Cancer Lett. 2009 Jan;273(1):44-54.

Selivanov VA, Zeak JA, Roca J, Cascante M, Trucco M, Votyakova TV. The role of external and matrix ph in mitochondrial reactive oxygen species generation. J Biol Chem. 2008 Oct;283(43):29292-300.

 

Pachón OG, Azqueta A, Lavaggi ML, López de Cerain A, Creppy E, Collins A, Cerecetto H, González M, Centelles JJ, Cascante M. Antitumoral effect of phenazine N5,N10-dioxide derivatives on Caco-2 cells Chem Res Toxicol. 2008 Aug;21(8):1578-85.

 

Frederiks WM, Vizan P, Bosch KS, Vreeling-Sindelárová H, Boren J, Cascante M. Elevated activity of the oxidative and non-oxidative pentose phosphate pathway in (pre)neoplastic lesions in rat liver. Int J Exp Pathol. 2008 Aug;89(4):232-40.

 

Touriño S, Lizárraga D, Carreras A, Lorenzo S, Ugartondo V, Mitjans M, Vinardell MP, Juliá L, Cascante M, Torres JL. Highly Galloylated Tannin Fractions from Witch Hazel (Hamamelis virginiana) Bark: Electron Transfer Capacity, In Vitro Antioxidant Activity, and Effects on Skin-Related Cells. Chem Res Toxicol. 2008 Mar;21(3):696-704.

 

Vizán, P.; Mazurek, S. and Cascante, M. Robust metabolic adaptation underlying tumor progression. Metabolomics 2008; 4:1-12. DOI: 10.1007/s11306-007-0101-3.

 

Ortega F, Cascante M, Acerenza L. Kinetic properties required for sustained or paradoxical control of metabolic fluxes under large changes in enzyme activities. J Theor Biol. 2007 Jun;252(3)569-73.

 

Selivanov VA, de Atauri P, Centelles JJ, Cadefau J, Parra J, Cussó R, Carreras J, Cascante M. The changes in the energy metabolism of human muscle induced by training. J Theor Biol. 2007 Jun;252(3):402-10.

 

	Lizarraga D, Lozano C, Briede JJ, van Delft JH, Tourino S, Centelles JJ, Torres JL, Cascante M. The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts. FEBS J. 2007 Sep;274(18):4802-4811.
	Vera-Gonzalez J, Curto R, Cascante M, Torres NV. Detection of potential enzyme targets by metabolic modelling and optimization. Application to a simple enzymopathy.Bioinformatics. 2007 Sep; 23(17):2281-2289.

Vizan P, Alcarraz-Vizan G, Diaz-Moralli S, Rodriguez-Prados JC, Zanuy M, Centelles JJ, Jauregui O, Cascante M. Quantification of Intracellular Phosphorylated Carbohydrates in HT29 Human Colon Adenocarcinoma Cell Line Using Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry Anal Chem. 2007 Jul 1;79(13):5000-5005.

 

Centelles J. J, Ramos-Montoya A, Lim S, Bassilian S, Boros L. G, Marín S, Cascante M, Lee W-N P. Metabolic profile and quantification of deoxyribose synthesis pathways in HepG2 cells. Metabolomics 2007 Jun;3(2):105-111. DOI: 10.1007/s11306-006-0049-8.

 

Pachon G, Rasoanaivo H, Azqueta A, Rakotozafy JC, Raharisololalao A, De Cerain AL, De Lapuente J, Borras M, Moukha S, Centelles JJ, Creppy EE, Cascante M. Anticancer effect of a new benzophenanthridine isolated from Zanthoxylum madagascariense (Rutaceline).In Vivo. 2007 Mar-Apr;21(2):417-22.

Azqueta A, Arbillaga L, Pachon G, Cascante M, Creppy EE, Cerain AL. A quinoxaline 1,4-di-N-oxide derivative induces DNA oxidative damage not attenuated by vitamin C and E treatment.Chem Biol Interact. 2007 Jun 30;168(2):95-105.

	Selivanov V, Krause S, Roca J, Cascante M. Modeling of Spatial Metabolite Distributions in the Cardiac Sarcomere. Biophys J. 2007 May;92(10):3492-500.
	Isvoran A, Vilaseca E, Ortega F, Cascante M, Mas F. About implementing a Monte Carlo simulation algorithm for enzymatic reactions in crowded media. J Serb Chem Soc. 2006;71(1):75-86.

Selivanov VA, Sukhomlin T, Centelles JJ, Lee PW, Cascante M. Integration of enzyme kinetic models and isotopomer distribution analysis for studies of in situ cell operation. BMC Neurosci. 2006 Oct 30;7 Suppl 1:S7 [Epub ahead of print].

 

Medina, I.; Lois, S.; Lizarraga, D.; Pazos, M.; Tourino, S.; Cascante, M.; Torres, J. L. Functional Fatty Fish Supplemented with Grape Procyanidins. Antioxidant and Proapoptotic Properties on Colon Cell Lines.J. Agric. Food Chem.; (Article); 2006; 54(10); 3598-3603.

 

Reyes FJ, Centelles JJ, Lupianez JA, Cascante M. (2alpha,3beta)-2,3-Dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. FEBS Lett. 2006 Oct;580(27):6302-10.

Ramos-Montoya A, Lee WN, Bassilian S, Lim S, Trebukhina RV, Kazhyna MV, Ciudad CJ, Noe V, Centelles JJ, Cascante M. Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer. Int J Cancer. 2006 Dec;119(12):2733-41.

Selivanov VA, Marin S, Lee PW, Cascante M. Software for dynamic analysis of tracer-based metabolomic data: estimation of metabolic fluxes and their statistical analysis. Bioinformatics. 2006 Nov;22(22):2806-12.

Ortega F, Garces JL, Mas F, Kholodenko BN, Cascante M. Bistability from double phosphorylation in signal transduction. Kinetic and structural requirements. FEBS J. 2006 Sep;273(17):3915-26. Review.

Sillero A, Selivanov VA, Cascante M. Pentose phosphate and Calvin cycles similarities and three-dimensional views. Biochem Mol Biol Edu 2006 Jul;34(4):275-277.

 

Rodriguez-Caso C, Montanez R, Cascante M, Sanchez-Jimenez F, Medina MA. Mathematical modeling of polyamine metabolism in mammals. J Biol Chem. 2006 May;281(31):21799-812.

 

Lozano C, Julia L, Jimenez A, Tourino S, Centelles JJ, Cascante M, Torres JL. Electron-transfer capacity of catechin derivatives and influence on the cell cycle and apoptosis in HT29 cells. FEBS J. 2006 Jun;273(11):2475-86.

Cespedes MV, Sancho FJ, Guerrero S, Parreno M, Casanova I, Pavon MA, Marcuello E, Trias M, Cascante M, Capella G, Mangues R. K-Ras Asp12 mutant neither interacts with Raf, nor signals through Erk, and is less tumorigenic than K-Ras Val12. Carcinogenesis. 2006 May;27(11):2190-200.

de Atauri P, Ramirez MJ, Kuchel PW, Carreras J, Cascante M. Metabolic homeostasis in the human erythrocyte: in silico analysis. Biosystems. 2006 Feb-Mar;83(2-3):118-24.

 

Boren J, Ramos-Montoya A, Bosch KS, Vreeling H, Jonker A, Centelles JJ, Cascante M, Frederiks WM. In situ localization of transketolase activity in epithelial cells of different rat tissues and subcellularly in liver parenchymal cells. J Histochem Cytochem. 2006 Feb;54(2):191-9.

Research Groups of the Department
Department of Biochemistry and Molecular Biology