Integrative Systems Biology, Metabolomics and Cancer

Departament of Biochemistry and Molecular Biomedicine

 English    Catala


Consolidate research group of the Autonomous Government of Catalonia (2017SGR1033) from 1997. It belongs to Institute of Biomedicine of the Universitat de Barcelona (IBUB) and to the Reference Network of R+D+i on Theoretical and Computational Chemistry (XRQTC) of Catalonia.




Two Marie Skłodowska-Curie scholarships are offered as part of the project "TubInTrain: Tuning Tubulin Dynamics and Interactions to Face Neurotoxicity: a Multidisciplinary Approach for Training and Research". More information here and here. The deadline for applications is 11/11/2019.

Group Photo

About us

In our group we perform a multidisciplinary research, combining techniques from the fields of biochemistry, cellular and molecular biology and bioinformatics for an integrated analysis of biological samples. Our main research lines are:

Metabolomics and fluxomics

  • Metabolite measurement by GC/MS and LC/MS in samples with a special biomedical, biotechnological or industrial interest
  • Analysis of the isotopomeric distribution in different metabolites, which results from the incubation with substrates labelled with 13C.
  • Software development and application for metabolic fluxes quantification by using kinetic information and experimental metabolomic data
  • Characterization of metabolic adaptations that accompany:
      • cell differentiation
      • cell death
      • tumorogenesis
      • oncogene transformation
      • drug treatments

Cancer Therapy

  • Study of the differences in metabolism regulation between tumoral and non-tumoral cell lines.
  • Design of antitumoral therapies based on the inhibition of different key points of cancer cell metabolism.
  • Study of the antitumoral and antioxidant properties of bioactive polyphenols extracted out of subproducts from the agricultural and forest industries.
  • Characterization of the biological effect of new chemical compounds with antitumoral potential.

Control and regulation analysis of biochemical systems with biomedical or biothecnological purposes

  • Modeling of metabolic pathways and prediction of genetic manipulation consequences towards a therapeutic or industrial purpose.
  • Sofware package development using Mathematica(R) for the analysis and modeling of metabolic pathways.
  • Design analysis and optimization of metabolic pathway regulatory patterns.
  • Theoretical development and experimental application of  Metabolic Control Analysis (MCA) and  Biochemical Systems Theory (BST).
  • Modeling of biochemical systems using kinetic or stocastic methods.
  • Study of enzyme-enzyme interactions and biopolimers-enzymes binding.