Biologia de Sistemes Integrativa, Metabolòmica i Càncer 

Departament de Bioquímica i Biomedicina Molecular

 English    Catala

INICI - MEMBRES DEL GRUP - PUBLICACIONS - PROJECTES ACTUALS - ENLLAÇOS

 

PUBLICACIONS (ÚLTIMS CINC ANYS)

Á. Tényi, I. Cano, F. Marabita, N. Kiani, S.G. Kalko, E. Barreiro, P. Atauri, M. Cascante, D. Gomez-Cabrero, J. Roca, Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients, J. Transl. Med. 16 (2018) 34. doi:10.1186/s12967-018-1405-y.

I. Marín de Mas, E. Aguilar, E. Zodda, C. Balcells, S. Marin, G. Dallmann, T.M. Thomson, B. Papp, M. Cascante, Model-driven discovery of long-chain fatty acid metabolic reprogramming in heterogeneous prostate cancer cells, PLoS Comput. Biol. 14 (2018) e1005914. doi:10.1371/journal.pcbi.1005914.

M. Solé, C. Balcells, M. Crespo, J. Quirante, J. Badia, L. Baldomà, M. Font-Bardia, M. Cascante, Synthesis, characterization and biological actIVity of new cyclometallated platinum(IV) complexes containing a para-tolyl ligand, Dalt. Trans. 47 (2018) 8956–8971. doi:10.1039/c8dt01124a.

R. Rodríguez-Pérez, R. Cortés, A. Guamán, A. Pardo, Y. Torralba, F. Gómez, J. Roca, J.A. Barberà, M. Cascante, S. Marco, Instrumental drift removal in GC-MS data for breath analysis: The short-Term and long-Term temporal validation of putative biomarkers for COPD, J. Breath Res. 12 (2018) 36007. doi:10.1088/1752-7163/aaa492.

A. Jayaraman, P. Kumar, S. Marin, P. De Atauri, F. Mateo, T.M. Thomson, J.J. Centelles, S.F. Graham, M. Cascante, Untargeted metabolomics reveals distinct metabolic reprogramming in endothelial cells co-cultured with CSC and non-CSC prostate cancer cell subpopulations, PLoS One. 13 (2018) e0192175. doi:10.1371/journal.pone.0192175.

A. Rosato, L. Tenori, M. Cascante, P.R. De Atauri Carulla, V.A.P. Martins dos Santos, E. Saccenti, From correlation to causation: analysis of metabolomics data using systems biology approaches, Metabolomics. 14 (2018) 37. doi:10.1007/s11306-018-1335-y.

J.A. Kirwan, L. Brennan, D. Broadhurst, O. Fiehn, M. Cascante, W.B. Dunn, M.A. Schmidt, V. Velagapudi, Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for “Precision Medicine and Pharmacometabolomics Task Group”—The Metabolomics Society Initiative), Clin. Chem. 64 (2018) 1158–1182. doi:10.1373/clinchem.2018.287045.

M. Solé, C. Balcells, M. Crespo, J. Quirante, J. Badia, L. Baldomà, M. Font-Bardia, M. Cascante, Synthesis, characterization and biological actIVity of new cyclometallated platinum(IV) complexes containing a para-tolyl ligand, Dalt. Trans. 47 (2018) 8956–8971. doi:10.1039/c8dt01124a.

L. Millares, E. Barreiro, R. Cortes, A. Martinez-Romero, C. Balcells, M. Cascante, A.B. Enguita, C. Alvarez, R. Rami-Porta, J. Sánchez de Cos, L. Seijo, E. Monsó, Tumor-associated metabolic and inflammatory responses in early stage non-small cell lung cancer: Local patterns and prognostic significance, Lung Cancer. 122 (2018) 124–130. doi:10.1016/j.lungcan.2018.06.015.

V.A. Selivanov, A. Benito, A. Miranda, E. Aguilar, I.H. Polat, J.J. Centelles, A. Jayaraman, P.W.N. Lee, S. Marin, M. Cascante, MIDcor, an R-program for deciphering mass interferences in mass spectra of metabolites enriched in stable isotopes., BMC Bioinformatics. 18 (2017) 88. doi:10.1186/s12859-017-1513-3.

M. Chong, A. Jayaraman, S. Marin, V. Selivanov, P.R. de Atauri Carulla, D.A. Tennant, M. Cascante, U.L. Günther, C. Ludwig, Combined Analysis of NMR and MS Spectra (CANMS)., Angew. Chem. Int. Ed. Engl. 56 (2017) 4140–4144. doi:10.1002/anie.201611634.

I. Marín de Mas, S. Marín, G. Pachón, J.C. Rodríguez-Prados, P. Vizán, J.J. Centelles, R. Tauler, A. Azqueta, V. Selivanov, A. López de Ceraín, M. Cascante, Unveiling the Metabolic Changes on Muscle Cell Metabolism Underlying p-Phenylenediamine Toxicity, Front. Mol. Biosci. 4 (2017) 8. doi:10.3389/fmolb.2017.00008.

S.A.C. Figueiredo, J.A.R. Salvador, R. Cortés, M. Cascante, Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation, Eur. J. Med. Chem. 138 (2017) 422–437. doi:10.1016/j.ejmech.2017.06.029.

S.A.C. Figueiredo, J.A.R. Salvador, R. Cortés, M. Cascante, Design, synthesis and biological evaluation of novel C-29 carbamate celastrol derivatives as potent and selective cytotoxic compounds, Eur. J. Med. Chem. 139 (2017) 836–848. doi:10.1016/j.ejmech.2017.08.058.

N. Trempolec, J.P. Muñoz, K. Slobodnyuk, S. Marin, M. Cascante, A. Zorzano, A.R. Nebreda, Induction of oxidative metabolism by the p38α/MK2 pathway, Sci. Rep. 7 (2017) 11367. doi:10.1038/s41598-017-11309-7.

M. Tarrado‐Castellarnau, P. de Atauri, J. Tarragó‐Celada, J. Perarnau, M. Yuneva, T.M. Thomson, M. Cascante, De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition, Mol. Syst. Biol. 13 (2017) 940. doi:10.15252/msb.20167321.

E. Bauer, X. Domingo, C. Balcells, I.H. Polat, M. Crespo, J. Quirante, J. Badía, L. Baldomà, M. Font-Bardia, M. Cascante, Synthesis, characterization and biological actIVity of new cyclometallated platinum(IV) iodido complexes, Dalt. Trans. 46 (2017) 14973–14987. doi:10.1039/c7dt03448b.

J. Pey, E. San José-Eneriz, M.C. Ochoa, I. Apaolaza, P. De Atauri, A. Rubio, X. Cendoya, E. Miranda, L. Garate, M. Cascante, A. Carracedo, X. Agirre, F. Prosper, F.J. Planes, In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer, Sci. Rep. 7 (2017) 14358. doi:10.1038/s41598-017-14067-8.

L. Sánchez-Cid, M. Pons, J.J. Lozano, N. Rubio, M. Guerra-Rebollo, A. Soriano, L. Paris-Coderch, M.F. Segura, R. Fueyo, J. Arguimbau, E. Zodda, R. Bermudo, I. Alonso, X. Caparrós, M. Cascante, A. Rafii, Y. Kang, M. Martínez-Balbás, S.J. Weiss, J. Blanco, M. Muñoz, P.L. Fernández, T.M. Thomson, MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells., Oncotarget. 8 (2017) 83384–83406. doi:10.18632/oncotarget.20698.

M. van Rijswijk, C. Beirnaert, C. Caron, M. Cascante, V. Dominguez, W.B. Dunn, T.M.D. Ebbels, F. Giacomoni, A. Gonzalez-Beltran, T. Hankemeier, K. Haug, J.L. Izquierdo-Garcia, R.C. Jimenez, F. Jourdan, N. Kale, M.I. Klapa, O. Kohlbacher, K. Koort, K. Kultima, G. Le Corguillé, P. Moreno, N.K. Moschonas, S. Neumann, C. O’Donovan, M. Reczko, P. Rocca-Serra, A. Rosato, R.M. Salek, S.-A. Sansone, V. Satagopam, D. Schober, R. Shimmo, R.A. Spicer, O. Spjuth, E.A. Thévenot, M.R. Viant, R.J.M. Weber, E.L. Willighagen, G. Zanetti, C. Steinbeck, The future of metabolomics in ELIXIR, F1000Research. 6 (2017) 1649. doi:10.12688/f1000research.12342.2.

A. Benito, I.H. Polat, V. Noé, C.J. Ciudad, S. Marin, M. Cascante, Glucose-6-phosphate dehydrogenase and transketolase modulate breast cancer cell metabolic reprogramming and correlate with poor patient outcome, Oncotarget. 8 (2017) 106693–106706. doi:10.18632/oncotarget.21601.

M. Tarrado‐Castellarnau, P. de Atauri, J. Tarragó‐Celada, J. Perarnau, M. Yuneva, T.M. Thomson, M. Cascante, De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition, Mol. Syst. Biol. 13 (2017) 940. doi:10.15252/msb.20167321.

E. Bauer, X. Domingo, C. Balcells, I.H. Polat, M. Crespo, J. Quirante, J. Badía, L. Baldomà, M. Font-Bardia, M. Cascante, Synthesis, characterization and biological actIVity of new cyclometallated platinum(IV) iodido complexes, Dalt. Trans. 46 (2017) 14973–14987. doi:10.1039/c7dt03448b.

I. Marín De Mas, E. Fanchon, B. Papp, S. Kalko, J. Roca, M. Cascante, Molecular mechanisms underlying COPD-muscle dysfunction unveiled through a systems medicine approach, Bioinformatics. 33 (2017) 95–103. doi:10.1093/bioinformatics/btw566.

M. Tarrado-Castellarnau, P. de Atauri, M. Cascante, Oncogenic regulation of tumor metabolic reprogramming, Oncotarget. 7 (2016) 62726–62753. doi:10.18632/oncotarget.10911.

Á. Tényi, P. de Atauri, D. Gomez-Cabrero, I. Cano, K. Clarke, F. Falciani, M. Cascante, J. Roca, D. Maier, ChainRank, a chain prioritisation method for contextualisation of biological networks, BMC Bioinformatics. 17 (2016) 17. doi:10.1186/s12859-015-0864-x.

F.J. Reyes-Zurita, E.E. Rufino-Palomares, L. García-Salguero, J. Peragón, P.P. Medina, A. Parra, M. Cascante, J.A. Lupiáñez, Maslinic acid, a natural triterpene, induces a death receptor-mediated apoptotic mechanism in caco-2 p53-deficient colon adenocarcinoma cells, PLoS One. 11 (2016) e0146178. doi:10.1371/journal.pone.0146178.

B.M.F. Gonçalves, J.A.R. Salvador, S. Marín, M. Cascante, Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives, Eur. J. Med. Chem. 114 (2016) 101–117. doi:10.1016/j.ejmech.2016.02.057.

C. Foguet, S. Marin, V.A. Selivanov, E. Fanchon, W.-N.P. Lee, J.J. Guinovart, P. de Atauri, M. Cascante, HepatoDyn: A Dynamic Model of Hepatocyte Metabolism That Integrates 13C Isotopomer Data., PLoS Comput. Biol. 12 (2016) e1004899. doi:10.1371/journal.pcbi.1004899.

A.E. Alekseev, R. Guzun, S. Reyes, C. Pison, U. Schlattner, V.A. Selivanov, M. Cascante, Restrictions in ATP diffusion within sarcomeres can provoke ATP-depleted zones impairing exercise capacity in chronic obstructive pulmonary disease., Biochim. Biophys. Acta. 1860 (2016) 2269–78. doi:10.1016/j.bbagen.2016.04.018.

M. Cvijovic, T. Höfer, J. Aćimović, L. Alberghina, E. Almaas, D. Besozzi, A. Blomberg, T. Bretschneider, M. Cascante, O. Collin, P. de Atauri, C. Depner, R. Dickinson, M. Dobrzynski, C. Fleck, J. Garcia-Ojalvo, D. Gonze, J. Hahn, H.M. Hess, S. Hollmann, M. Krantz, U. Kummer, T. Lundh, G. Martial, V.M. Dos Santos, A. Mauer-Oberthür, B. Regierer, B. Skene, E. Stalidzans, J. Stelling, B. Teusink, C.T. Workman, S. Hohmann, Strategies for structuring interdisciplinary education in Systems Biology: an European perspective., NPJ Syst. Biol. Appl. 2 (2016) 16011. doi:10.1038/npjsba.2016.11.

E. Aguilar, I. Marin de Mas, E. Zodda, S. Marin, F. Morrish, V. Selivanov, Ó. Meca-Cortés, H. Delowar, M. Pons, I. Izquierdo, T. Celià-Terrassa, P. de Atauri, J.J. Centelles, D. Hockenbery, T.M. Thomson, M. Cascante, Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program., Stem Cells. 34 (2016) 1163–76. doi:10.1002/stem.2286.

S. Diaz-Moralli, E. Aguilar, S. Marin, J.F. Coy, M. Dewerchin, M.R. Antoniewicz, O. Meca-Cortés, L. Notebaert, B. Ghesquière, G. Eelen, T.M. Thomson, P. Carmeliet, M. Cascante, A key role for transketolase-like 1 in tumor metabolic reprogramming., Oncotarget. 7 (2016) 51875–51897. doi:10.18632/oncotarget.10429.

A. Escolà, M. Crespo, C. López, J. Quirante, A. Jayaraman, I.H. Polat, J. Badía, L. Baldomà, M. Cascante, On the stability and biological behavior of cyclometallated Pt(IV) complexes with halido and aryl ligands in the axial positions., Bioorg. Med. Chem. 24 (2016) 5804–5815. doi:10.1016/j.bmc.2016.09.037.

R.D. Beger, W. Dunn, M.A. Schmidt, S.S. Gross, J.A. Kirwan, M. Cascante, L. Brennan, D.S. Wishart, M. Oresic, T. Hankemeier, D.I. Broadhurst, A.N. Lane, K. Suhre, G. Kastenm�ller, S.J. Sumner, I. Thiele, O. Fiehn, R. Kaddurah-Daouk, for “Precision Medicine, Metabolomics enables precision medicine: “A White Paper, Community Perspective,” Metabolomics. 12 (2016) 149. doi:10.1007/s11306-016-1094-6.

M. Romero, M. Zanuy, E. Rosell, M. Cascante, J. Piulats, M. Font-Bardia, J. Balzarini, E. De Clerq, M.D. Pujol, Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties Dedicated to the Professor Rosa Maria Claramunt on the occasion of this 65 birthday, Eur. J. Med. Chem. 90 (2015) 491–496. doi:10.1016/j.ejmech.2014.11.060.

M. Binns, P. de Atauri, A. Vlysidis, M. Cascante, C. Theodoropoulos, Sampling with poling-based flux balance analysis: Optimal versus sub-optimal flux space analysis of Actinobacillus succinogenes, BMC Bioinformatics. 16 (2015) 49. doi:10.1186/s12859-015-0476-5.

J. Albert, R. Bosque, M. Crespo, J. Granell, C. López, R. Martín, A. González, A. Jayaraman, J. Quirante, C. Calvis, J. Badía, L. Baldomà, M. Font-Bardia, M. Cascante, R. Messeguer, Neutral and ionic platinum compounds containing a cyclometallated chiral primary amine: synthesis, antitumor activity, DNA interaction and topoisomerase I-cathepsin B inhibition, Dalt. Trans. 44 (2015) 13602–13614. doi:10.1039/c5dt01713k.

M. Tarrado-Castellarnau, R. Cortés, M. Zanuy, J. Tarragó-Celada, I.H. Polat, R. Hill, T.W.M. Fan, W. Link, M. Cascante, Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition, Pharmacol. Res. 102 (2015) 218–234. doi:10.1016/j.phrs.2015.09.009.

S. Schoors, K. De Bock, A.R. Cantelmo, M. Georgiadou, B. Ghesquière, S. Cauwenberghs, A. Kuchnio, B.W. Wong, A. Quaegebeur, J. Goveia, F. Bifari, X. Wang, R. Blanco, B. Tembuyser, I. Cornelissen, A. Bouché, S. Vinckier, S. Diaz-Moralli, H. Gerhardt, S. Telang, M. Cascante, J. Chesney, M. Dewerchin, P. Carmeliet, Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis, Cell Metab. 19 (2014) 37–48. doi:10.1016/j.cmet.2013.11.008.

I. Pastor, L. Pitulice, C. Balcells, E. Vilaseca, S. Madurga, A. Isvoran, M. Cascante, F. Mas, Effect of crowding by Dextrans in enzymatic reactions, Biophys. Chem. 185 (2014) 8–13. doi:10.1016/j.bpc.2013.10.006.

G. Alcarraz-Vizán, S. Sánchez-Tena, M.P. Moyer, M. Cascante, Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: Trichostatin A as a case study, Biochim. Biophys. Acta - Gen. Subj. 1840 (2014) 1634–1639. doi:10.1016/j.bbagen.2013.12.024.

M.J. Ramírez-Bajo, P. De Atauri, F. Ortega, H. V. Westerhoff, J.L. Gelpí, J.J. Centelles, M. Cascante, Effects of cadmium and mercury on the upper part of skeletal muscle glycolysis in mice, PLoS One. 9 (2014) e80018. doi:10.1371/journal.pone.0080018.

R. Cortés, M. Tarrado-Castellarnau, D. Talancón, C. López, W. Link, D. Ruiz, J.J. Centelles, J. Quirante, M. Cascante, A novel cyclometallated Pt(II)-ferrocene complex induces nuclear FOXO3a localization and apoptosis and synergizes with cisplatin to inhibit lung cancer cell proliferation, Metallomics. 6 (2014) 622–633. doi:10.1039/c3mt00194f.

C. Obiol-Pardo, G. Alcarraz-Vizán, S. Díaz-Moralli, M. Cascante, J. Rubio-Martinez, Design of an interface peptide as new inhibitor of human glucose-6-phosphate dehydrogenase, J. Mol. Graph. Model. 49 (2014) 110–117. doi:10.1016/j.jmgm.2014.02.004.

C. Balcells, I. Pastor, E. Vilaseca, S. Madurga, M. Cascante, F. Mas, Macromolecular crowding effect upon in vitro enzyme kinetics: Mixed activation-diffusion control of the oxidation of NADH by pyruvate catalyzed by lactate dehydrogenase, J. Phys. Chem. B. 118 (2014) 4062–4068. doi:10.1021/jp4118858.

J. Albert, R. Bosque, M. Crespo, G. García, J. Granell, C. López, M.V. Lovelle, R. Qadir, A. González, A. Jayaraman, E. Mila, R. Cortés, J. Quirante, C. Calvis, R. Messeguer, J. Badía, L. Baldomà, M. Cascante, Cyclopalladated primary amines: A preliminary study of antiproliferative activity through apoptosis induction, Eur. J. Med. Chem. 84 (2014) 530–536. doi:10.1016/j.ejmech.2014.07.046.

A. Martín-Bernabé, R. Cortés, S.G. Lehmann, M. Seve, M. Cascante, S. Bourgoin-Voillard, Quantitative proteomic approach to understand metabolic adaptation in non-small cell lung cancer, J. Proteome Res. 13 (2014) 4695–4704. doi:10.1021/pr500327v.

E. Molinar-Toribio, J. Pérez-Jiménez, S. Ramos-Romero, L. Lluís, V. Sánchez-Martos, N. Taltavull, M. Romeu, M. Pazos, L. Méndez, A. Miranda, M. Cascante, I. Medina, J.L. Torres, Cardiovascular disease-related parameters and oxidative stress in SHROB rats, a model for metabolic syndrome, PLoS One. 9 (2014) e104637. doi:10.1371/journal.pone.0104637.

S. Guzmán, S. Marin, A. Miranda, V.A. Selivanov, J.J. Centelles, R. Harmancey, F. Smih, A. Turkieh, Y. Durocher, A. Zorzano, P. Rouet, M. Cascante, 13C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes, BMC Syst. Biol. 8 (2014) 109. doi:10.1186/s12918-014-0109-z.

D. Gomez-Cabrero, J. Menche, I. Cano, I. Abugessaisa, M. Huertas-Migueláñ, A. Tenyi, I.M. de Mas, N.A. Kiani, F. Marabita, F. Falciani, K. Burrowes, D. Maier, P. Wagner, V. Selivanov, M. Cascante, J. Roca, A.L. Barabási, J. Tegnér, Systems Medicine: From molecular features and models to the clinic in COPD, J. Transl. Med. 12 (2014) S4. doi:10.1186/1479-5876-12-S2-S4.

I. Cano, V. Selivanov, D. Gomez-Cabrero, J. Tegnér, J. Roca, P.D. Wagner, M. Cascante, Oxygen pathway modeling estimates high reactive oxygen species production above the highest permanent human habitation, PLoS One. 9 (2014) e111068. doi:10.1371/journal.pone.0111068.

I. Cano, Á. Tényi, C. Schueller, M. Wolff, M.M.H. Migueláñez, D. Gomez-Cabrero, P. Antczak, J. Roca, M. Cascante, F. Falciani, D. Maier, The COPD knowledge base: Enabling data analysis and computational simulation in translational COPD research, J. Transl. Med. 12 (2014) S6. doi:10.1186/1479-5876-12-S2-S6.

I. Cano, M. Lluch-Ariet, D. Gomez-Cabrero, D. Maier, S. Kalko, M. Cascante, J. Tegnér, F. Miralles, D. Herrera, J. Roca, Biomedical research in a digital health framework, J. Transl. Med. 12 (2014) S10. doi:10.1186/1479-5876-12-S2-S10.

M. Cascante, P. de Atauri, D. Gomez-Cabrero, P. Wagner, J.J. Centelles, S. Marin, I. Cano, F. Velickovski, I.M. de Mas, D. Maier, J. Roca, P. Sabatier, Workforce preparation: The biohealth computing model for master and phd students, J. Transl. Med. 12 (2014) S11. doi:10.1186/1479-5876-12-S2-S11.

F. Miralles, D. Gomez-Cabrero, M. Lluch-Ariet, J. Tegnér, M. Cascante, J. Roca, Predictive medicine: Outcomes, challenges and opportunities in the Synergy-COPD project, J. Transl. Med. 12 (2014) S12. doi:10.1186/1479-5876-12-S2-S12.

D. Gomez-Cabrero, M. Lluch-Ariet, J. Tegnér, M. Cascante, F. Miralles, J. Roca, Synergy-COPD: A systems approach for understanding and managing chronic diseases, J. Transl. Med. 12 (2014) S2. doi:10.1186/1479-5876-12-S2-S2.

J. Roca, C. Vargas, I. Cano, V. Selivanov, E. Barreiro, D. Maier, F. Falciani, P. Wagner, M. Cascante, J. Garcia-Aymerich, S. Kalko, I.M. De Mas, J. Tegnér, J. Escarrabill, Alvar Agustí, D. Gomez-Cabrero, Chronic Obstructive Pulmonary Disease heterogeneity: Challenges for health risk assessment, stratification and management, J. Transl. Med. 12 (2014) S3. doi:10.1186/1479-5876-12-S2-S3.

               

INICI - MEMBRES DEL GRUP - PUBLICACIONS - PROJECTES ACTUALS - ENLLAÇOS