Càncer

DEPARTAMENT DE BIOQUÍMICA I BIOLOGIA MOLECULAR

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Càncer

Personal Adscrit
Investigador/a Principal	Josep Maria Argiles Huguet
Personal de plantilla	Silvia Busquets Rius, Francesc Xavier López Soriano
Col.laboradors	Elisabet Ametller Pastallé, Maite Figueras Polo, Gemma Fuster Orellana, Mireia Olivan Riera
Línies de recerca
La caquèxia és una síndrome associada a diversos estats patològics, com creixement de tumors, infeccions cròniques, SIDA o traumes severs; es caracteritza principalment per una pèrdua important de massa corporal. El nostre grup de recerca s’ha interessat per l’estudi dels mecanismes moleculars involucrats en aquesta síndrome, usant tumors experimentals com a model. Els estudis en aquest camp ens han permès concloure que el factor alfa de la necrosi tumoral, una citoquina produïda bàsicament per macròfags, és responsable de la majoria dels canvis metabòlics associats a la caquèxia del càncer, especialment els que estàn relacionats amb un augment de la movilització de les proteïnes musculars. Addicionalment, hem identificat el sistema proteolític que s’activa en aquestes condicions: la ruta proteolítica depenent de l’ATP i de la ubiqüitina. Actualment, estem estudiant la regulació d’aquest sistema proteolític i altres mecanismes involucrats en la caquèxia del càncer (com l’activació de proteïnes no acoblants o l’apoptosi de cèl-lules del muscle esqueletal), per a poder dissenyar noves estratègies terapèutiques per a revertir aquesta condició patològica.
Publicacions relevants Llista completa
Costelli P, Muscaritoli M, Bossola M, Penna F, Reffo P, Bonetto A, Busquets S, Bonelli G, Lopez-Soriano FJ, Doglietto GB, Argiles JM, Baccino FM, Rossi Fanelli F. IGF-1 IS DOWN-REGULATED IN EXPERIMENTAL CANCER CACHEXIA. (2006) Am J Physiol Regul Integr Comp Physiol. . (PubMedId: 16614058 Busquets S, Garcia-Martinez C, Olivan M, Barreiro E, Lopez-Soriano FJ, Argiles JM. Overexpression of UCP3 in both murine and human myotubes is linked with the activation of proteolytic systems: a role in muscle wasting? (2006) Biochim Biophys Acta. 1760(2):253-8. Epub 2005 Nov 15. (PubMedId: 16337086 Almendro V, Busquets S, Ametller E, Carbo N, Figueras M, Fuster G, Argiles JM, Lopez-Soriano FJ. Effects of interleukin-15 on lipid oxidation: disposal of an oral [(14)C]-triolein load. (2006) Biochim Biophys Acta. 1761(1):37-42. Epub 2006 Jan 18. (PubMedId: 16458591 Busquets S, Ametller E, Fuster G, Olivan M, Raab V, Argiles JM, Lopez-Soriano FJ. Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model. (2006) Cancer Lett. . (PubMedId: 16466851 Argiles JM, Busquets S, Lopez-Soriano FJ. Cytokines as mediators and targets for cancer cachexia. (2006) Cancer Treat Res. 130:199-217. (PubMedId: 16610709 Lopez-Soriano J, Chiellini C, Maffei M, Grimaldi PA, Argiles JM. Roles of Skeletal Muscle and Peroxisome Proliferator-Activated Receptors in the Development and Treatment of Obesity. (2006) Endocr Rev. . (PubMedId: 16556851 Moore-Carrasco R, Garcia-Martinez C, Busquets S, Ametller E, Barreiro E, Lopez-Soriano FJ, Argiles JM. The AP-1/CJUN signaling cascade is involved in muscle differentiation: implications in muscle wasting during cancer cachexia. (2006) FEBS Lett. 580(2):691-6. Epub 2006 Jan 5. (PubMedId: 16412434 Argiles JM. Cancer-associated malnutrition. (2005) Eur J Oncol Nurs. 9 Suppl 2:S39-50. (PubMedId: 16437757 Busquets S, Almendro V, Barreiro E, Figueras M, Argiles JM, Lopez-Soriano FJ. Activation of UCPs gene expression in skeletal muscle can be independent on both circulating fatty acids and food intake. Involvement of ROS in amodel of mouse cancer cachexia. (2005) FEBS Lett. 579(3):717-22. (PubMedId: 15670834 Barreiro E, de la Puente B, Busquets S, Lopez-Soriano FJ, Gea J, Argiles JM. Both oxidative and nitrosative stress are associated with muscle wasting in tumour-bearing rats. (2005) FEBS Lett. 579(7):1646-52. (PubMedId: 15757655 Argiles JM, Busquets S, Felipe A, Lopez-Soriano FJ. Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopenia. (2005) Int J Biochem Cell Biol. 37(5):1084-104. Epub 2004 Dec 30. (PubMedId: 15743680 Argiles JM, Busquets S, Lopez-Soriano FJ. The pivotal role of cytokines in muscle wasting during cancer. (2005) Int J Biochem Cell Biol. 37(8):1609-19. Epub 2005 Apr 22. (PubMedId: 15878837 Argiles JM, Busquets S, Lopez-Soriano FJ. The pivotal role of cytokines in muscle wasting during cancer. (2005) Int J Biochem Cell Biol. 37(10):2036-46. (PubMedId: 16105746 Almendro V, Carbo N, Busquets S, Lopez-Soriano J, Figueras M, Ametller E, Argiles JM, Lopez-Soriano FJ. Interleukin-15 decreases lipid intestinal absorption. (2005) Int J Mol Med. 15(6):963-7. (PubMedId: 15870900 Busquets S, Figueras MT, Meijsing S, Carbo N, Quinn LS, Almendro V, Argiles JM, Lopez-Soriano FJ. Interleukin-15 decreases proteolysis in skeletal muscle: a direct effect. (2005) Int J Mol Med. 16(3):471-6. (PubMedId: 16077957 Almendro V, Carbo N, Busquets S, Lopez-Soriano J, Figueras M, Ametller E, Argiles JM, Lopez-Soriano FJ. Interleukin-15 decreases lipid intestinal absorption. (2005) Int J Mol Med. 15(6):963-7. (PubMedId: 15870900 Busquets S, Figueras MT, Meijsing S, Carbo N, Quinn LS, Almendro V, Argiles JM, Lopez-Soriano FJ. Interleukin-15 decreases proteolysis in skeletal muscle: a direct effect. (2005) Int J Mol Med. 16(3):471-6. (PubMedId: 16077957 Costelli P, Muscaritoli M, Bossola M, Moore-Carrasco R, Crepaldi S, Grieco G, Autelli R, Bonelli G, Pacelli F, Lopez-Soriano FJ, Argiles JM, Doglietto GB, Baccino FM, Rossi Fanelli F. Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation. (2005) Int J Oncol. 26(6):1663-8. (PubMedId: 15870883 Figueras M, Busquets S, Carbo N, Almendro V, Argiles JM, Lopez-Soriano FJ. Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue. (2005) Int J Oncol. 27(3):855-60. (PubMedId: 16077938 Costelli P, Muscaritoli M, Bossola M, Moore-Carrasco R, Crepaldi S, Grieco G, Autelli R, Bonelli G, Pacelli F, Lopez-Soriano FJ, Argiles JM, Doglietto GB, Baccino FM, Rossi Fanelli F. Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation. (2005) Int J Oncol. 26(6):1663-8. (PubMedId: 15870883 Figueras M, Busquets S, Carbo N, Almendro V, Argiles JM, Lopez-Soriano FJ. Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue. (2005) Int J Oncol. 27(3):855-60. (PubMedId: 16077938 Argiles JM, Lopez-Soriano J, Almendro V, Busquets S, Lopez-Soriano FJ. Cross-talk between skeletal muscle and adipose tissue: a link with obesity? (2005) Med Res Rev. 25(1):49-65. (PubMedId: 15389734 Argiles JM, Busquets S, Garcia-Martinez C, Lopez-Soriano FJ. Mediators involved in the cancer anorexia-cachexia syndrome: past, present, and future. (2005) Nutrition. 21(9):977-85. (PubMedId: 16043325 Busquets S, Figueras MT, Fuster G, Almendro V, Moore-Carrasco R, Ametller E, Argiles JM, Lopez-Soriano FJ. Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting. (2004) Cancer Res. 64(18):6725-31. (PubMedId: 15374990 Argiles JM, Almendro V, Busquets S, Lopez-Soriano FJ. The pharmacological treatment of cachexia. (2004) Curr Drug Targets. 5(3):265-77. (PubMedId: 15058312 Figueras M, Busquets S, Carbo N, Barreiro E, Almendro V, Argiles JM, Lopez-Soriano FJ. Interleukin-15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour-bearing rats. (2004) FEBS Lett. 569(1-3):201-6. (PubMedId: 15225634 Lopez-Soriano J, Carbo N, Almendro V, Figueras M, Ribas V, Busquets S, Lopez-Soriano FJ, Argiles JM. Rat liver lipogenesis is modulated by interleukin-15. (2004) Int J Mol Med. 13(6):817-9. (PubMedId: 15138618 Carbo N, Costelli P, Busquets S, Lopez-Soriano J, Lopez-Soriano FJ, Baccino FM, Argiles JM. Effect of c-ski overexpression on the development of cachexia in mice bearing the Lewis lung carcinoma. (2004) Int J Mol Med. 14(4):719-23. (PubMedId: 15375607 Carbo N, Lopez-Soriano FJ, Argiles JM. Plasma from pregnant rats has anti-tumoural activity. (2004) Oncol Rep. 12(4):885-7. (PubMedId: 15375517 Costelli P, Carbo N, Busquets S, Lopez-Soriano FJ, Baccino FM, Argiles JM. Reduced protein degradation rates and low expression of proteolytic systems support skeletal muscle hypertrophy in transgenic miceoverexpressing the c-ski oncogene. (2003) Cancer Lett. 200(2):153-60. (PubMedId: 14568169 Costelli P, Aoki P, Zingaro B, Carbo N, Reffo P, Lopez-Soriano FJ, Bonelli G, Argiles JM, Baccino FM. Mice lacking TNFalpha receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody. (2003) Cell Death Differ. 10(9):997-1004. (PubMedId: 12934074 Argiles JM, Busquets S, Lopez-Soriano FJ. Cytokines in the pathogenesis of cancer cachexia. (2003) Curr Opin Clin Nutr Metab Care. 6(4):401-6. (PubMedId: 12806213 Busquets S, Aranda X, Ribas-Carbo M, Azcon-Bieto J, Lopez-Soriano FJ, Argiles JM. Tumour necrosis factor-alpha uncouples respiration in isolated rat mitochondria. (2003) Cytokine. 22(1-2):1-4. (PubMedId: 12946099 Argiles JM, Moore-Carrasco R, Busquets S, Lopez-Soriano FJ. Catabolic mediators as targets for cancer cachexia. (2003) Drug Discov Today. 8(18):838-44. (PubMedId: 12963320 Almendro V, Carbo N, Busquets S, Figueras M, Tessitore L, Lopez-Soriano FJ, Argiles JM. Sepsis induces DNA fragmentation in rat skeletal muscle. (2003) Eur Cytokine Netw. 14(4):256-9. (PubMedId: 14715419 Rabinovich RA, Figueras M, Ardite E, Carbo N, Troosters T, Filella X, Barbera JA, Fernandez-Checa JC, Argiles JM, Roca J. Increased tumour necrosis factor-alpha plasma levels during moderate-intensity exercise in COPD patients. (2003) Eur Respir J. 21(5):789-94. (PubMedId: 12765422 Coma M, Vicente R, Busquets S, Carbo N, Tamkun MM, Lopez-Soriano FJ, Argiles JM, Felipe A. Impaired voltage-gated K+ channel expression in brain during experimental cancer cachexia. (2003) FEBS Lett. 536(1-3):45-50. (PubMedId: 12586336 Argiles JM, Moore-Carrasco R, Fuster G, Busquets S, Lopez-Soriano FJ. Cancer cachexia: the molecular mechanisms. (2003) Int J Biochem Cell Biol. 35(4):405-9. (PubMedId: 12565701 Argiles JM, Busquets S, Lopez-Soriano FJ. The role of uncoupling proteins in pathophysiological states. (2002) Biochem Biophys Res Commun. 293(4):1145-52. (PubMedId: 12054495 Alvarez B, Carbo N, Lopez-Soriano J, Drivdahl RH, Busquets S, Lopez-Soriano FJ, Argiles JM, Quinn LS. Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissue. (2002) Biochim Biophys Acta. 1570(1):33-7. (PubMedId: 11960686 Alvarez B, Quinn LS, Busquets S, Quiles MT, Lopez-Soriano FJ, Argiles JM. Tumor necrosis factor-alpha exerts interleukin-6-dependent and -independent effects on cultured skeletal muscle cells. (2002) Biochim Biophys Acta. 1542(1-3):66-72. (PubMedId: 11853880 Carbo N, Busquets S, van Royen M, Alvarez B, Lopez-Soriano FJ, Argiles JM. TNF-alpha is involved in activating DNA fragmentation in skeletal muscle. (2002) Br J Cancer. 86(6):1012-6. (PubMedId: 11953838 Meijsing B, Carbo N, Lopez-Soriano FJ, Argiles JM. Effects of the phosphodiesterase-IV inhibitor EMD 95832/3 on tumour growth and cachexia in rats bearing the Yoshida AH-130 ascites hepatoma. (2002) Cancer Lett. 188(1-2):53-8. (PubMedId: 12406548 Bullo M, Garcia-Lorda P, Peinado-Onsurbe J, Hernandez M, Del Castillo D, Argiles JM, Salas-Salvado J. TNFalpha expression of subcutaneous adipose tissue in obese and morbid obese females: relationship to adipocyte LPL activity and leptinsynthesis. (2002) Int J Obes Relat Metab Disord. 26(5):652-8. (PubMedId: 12032749 Busquets S, Alvarez B, Lopez-Soriano FJ, Argiles JM. Branched-chain amino acids: a role in skeletal muscle proteolysis in catabolic states? (2002) J Cell Physiol. 191(3):283-9. (PubMedId: 12012323 Bossola M, Muscaritoli M, Costelli P, Nanni G, Tazza L, Panocchia N, Busquets S, Argiles J, Lopez-Soriano FJ, Grieco G, Baccino FM, Rossi Fanelli F, Castagneto M, Luciani G. Muscle ubiquitin m-rNA levels in patients with end-stage renal disease on maintenance hemodialysis. (2002) J Nephrol. 15(5):552-7. (PubMedId: 12455723 Bossola M, Muscaritoli M, Costelli P, Bellantone R, Pacelli F, Busquets S, Argiles J, Lopez-Soriano FJ, Civello IM, Baccino FM, Rossi Fanelli F, Doglietto GB. Increased muscle ubiquitin mRNA levels in gastric cancer patients. (2001) Am J Physiol Regul Integr Comp Physiol. 280(5):R1518-23. (PubMedId: 11294777 Rabinovich RA, Ardite E, Troosters T, Carbo N, Alonso J, Gonzalez de Suso JM, Vilaro J, Barbera JA, Polo MF, Argiles JM, Fernandez-Checa JC, Roca J. Reduced muscle redox capacity after endurance training in patients with chronic obstructive pulmonary disease. (2001) Am J Respir Crit Care Med. 164(7):1114-8. (PubMedId: 11673195 Carbo N, Lopez-Soriano J, Costelli P, Alvarez B, Busquets S, Baccino FM, Quinn LS, Lopez-Soriano FJ, Argiles JM. Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control. (2001) Biochim Biophys Acta. 1526(1):17-24. (PubMedId: 11287118 Busquets S, Alvarez B, Van Royen M, Figueras MT, Lopez-Soriano FJ, Argiles JM. Increased uncoupling protein-2 gene expression in brain of lipopolysaccharide-injected mice: role of tumour necrosis factor-alpha? (2001) Biochim Biophys Acta. 1499(3):249-56. (PubMedId: 11341972 Busquets S, Carbo N, Almendro V, Quiles MT, Lopez-Soriano FJ, Argiles JM. Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model. (2001) Cancer Lett. 167(1):33-8. (PubMedId: 11323096 Busquets S, Carbo N, Almendro V, Figueras M, Lopez-Soriano FJ, Argiles JM. Hyperlipemia: a role in regulating UCP3 gene expression in skeletal muscle during cancer cachexia? (2001) FEBS Lett. 505(2):255-8. (PubMedId: 11566186 Argiles JM, Lopez-Soriano FJ. Insulin and cancer (Review). (2001) Int J Oncol. 18(4):683-7. (PubMedId: 11251161 Argiles JM, Busquets S, Lopez-Soriano FJ. Metabolic interrelationships between liver and skeletal muscle in pathological states. (2001) Life Sci. 69(12):1345-61. (PubMedId: 11531159 Argiles JM, Meijsing SH, Pallares-Trujillo J, Guirao X, Lopez-Soriano FJ. Cancer cachexia: a therapeutic approach. (2001) Med Res Rev. 21(1):83-101. (PubMedId: 11135301 van Royen M, Carbo N, Busquets S, Alvarez B, Quinn LS, Lopez-Soriano FJ, Argiles JM. DNA fragmentation occurs in skeletal muscle during tumor growth: A link with cancer cachexia? (2000) Biochem Biophys Res Commun. 270(2):533-7. (PubMedId: 10753659 Busquets S, Garcia-Martinez C, Alvarez B, Carbo N, Lopez-Soriano FJ, Argiles JM. Calpain-3 gene expression is decreased during experimental cancer cachexia. (2000) Biochim Biophys Acta. 1475(1):5-9. (PubMedId: 10806331 Carbo N, Lopez-Soriano J, Costelli P, Busquets S, Alvarez B, Baccino FM, Quinn LS, Lopez-Soriano FJ, Argiles JM. Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats. (2000) Br J Cancer. 83(4):526-31. (PubMedId: 10945502 Busquets S, Alvarez B, van Royen M, Carbo N, Lopez-Soriano FJ, Argiles JM. Lack of effect of the cytokine suppressive agent FR167653 on tumour growth and cachexia in rats bearing the Yoshida AH-130 ascites hepatoma. (2000) Cancer Lett. 157(1):99-103. (PubMedId: 10893448 Argiles JM, Alvarez B, Carbo N, Busquets S, Van Royen M, Lopez-Soriano FJ. The divergent effects of tumour necrosis factor-alpha on skeletal muscle: implications in wasting. (2000) Eur Cytokine Netw. 11(4):552-9. (PubMedId: 11125297 Pallares-Trujillo J, Lopez-Soriano FJ, Argiles JM. Lipids: A key role in multidrug resistance? (Review). (2000) Int J Oncol. 16(4):783-98. (PubMedId: 10717249 Busquets S, Alvarez B, Llovera M, Agell N, Lopez-Soriano FJ, Argiles JM. Branched-chain amino acids inhibit proteolysis in rat skeletal muscle: mechanisms involved. (2000) J Cell Physiol. 184(3):380-4. (PubMedId: 10911370 Carbo N, Ribas V, Busquets S, Alvarez B, Lopez-Soriano FJ, Argiles JM. Short-term effects of leptin on skeletal muscle protein metabolism in the rat. (2000) J Nutr Biochem. 11(9):431-5. (PubMedId: 11091097 Bullo Bonet M, Garcia-Lorda P, Argiles JM, Salas-Salvado J. [The role of tumor necrosis factor in the control of fat reserve and obesity] (2000) Med Clin (Barc). 114(16):624-30. (PubMedId: 10846690 Pallares-Trujillo J, Carbo N, Lopez-Soriano FJ, Argiles JM. Does the mechanism responsible for TNF-mediated insulin resistance involve the proteasome? (2000) Med Hypotheses. 54(4):565-9. (PubMedId: 10859639 Argiles JM, Lopez-Soriano FJ. New mediators in cancer cachexia. (2000) Nestle Nutr Workshop Ser Clin Perform Programme. discussion 163-5. (PubMedId: 11490571

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