| URL: | http://www.bq.ub.es/recep/CV/petit/receptor.html |
Personal Adscrit |
| Investigador/a Principal | Rafael Franco Fernandez |
| Personal de plantilla | Enric Isidre Canela Campos, Vicent Casadó Burillo, Francisco Ciruela Alferez, Antoni Cortes Tejedor, Mª del Carme Lluis Biset, Josefa Mallol Montero |
| Col.laboradors | Laia Barceló , Jordi Bonaventura Morera, Nuria Cabello Gil de pareja, Laia Canela Pujol, Paulina Carriba Dominguez, Carla Ferrada Maass, Jorge Gandia Sanchez, Eduard Gracia Sanchez, Daniel james Marcellino , Jose maria Martinez Navio, Estefania Moreno , Gemma Navarro Brugal, Barbara Riera Rousset, Marta Riera Somalo, Aroa Soriano Fernandez |
| Visitants | Montserrat Barriga Moreno |
Línies de recerca |
1. Funció fisiològica dels heteròmeros de receptors de membrana neuronal amb especial rellevància en Parkinson, esquizofrenia, Alzheimer i drogadicció.
2.Identificació de nous heteròmers en el sistema nervios central
3.Identificació de noves interaccions receptor-proteïna d’especial rellevància en la funció neuronal
4.Síntesis i evaluació de noves molècules farmacològiques que interaccionen amb heteròmers de receptors de membrana
5.Tècniques de genòmica per l’estudi de malalties neurològiques i neuropsiquiàtriques
6.Bases moleculars de la plasticitat neuronal. Aprenentatge i memòria
7. Neuroimmunologia. Identificació i caracterizació de receptors de neurotransmisors en limfòcits
8. Identificació de noves interaccions receptor-proteïna en el sistema cardiovascular
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Publicacions relevantsLlista completa |
- Hove-Madsen L, Prat-Vidal C, Llach A, Ciruela F, Casado V, Lluis C, Bayes-Genis A, Cinca J, Franco R.. Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release. (2007) . 72(2):292-302. (PubMedId: 17014834
- Pacheco R, Oliva H, Martinez-Navio JM, Climent N, Ciruela F, Gatell JM, Gallart T, Mallol J, Lluis C, Franco R.. Glutamate released by dendritic cells as a novel modulator of T cell activation. (2007) J Immunol. 177(10):6695-704. (PubMedId: 17082582
- Ciruela F, Casado V, Rodrigues RJ, Lujan R, Burgueno J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cortes A, Canela EI, Lopez-Gimenez JF, Milligan G, Lluis C, Cunha RA, Ferre S, Franco R. Presynaptic control of striatal glutamatergic neurotransmission by
adenosine A1-A2A receptor heteromers. (2006) J Neurosci. 26(7):2080-7. (PubMedId: 16481441
- Franco R, Casado V, Mallol J, Ferrada C, Ferre S, Fuxe K, Cortes A, Ciruela F, Lluis C, Canela EI. THE "TWO-STATE DIMER RECEPTOR MODEL". A GENERAL MODEL FOR RECEPTOR DIMERS. (2006) Mol Pharmacol. 69(6):1905-12 (PubMedId: 16501032
- Saura J, Angulo E, Ejarque A, Casado V, Tusell JM, Moratalla R, Chen JF, Schwarzschild MA, Lluis C, Franco R, Serratosa J.. Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia. (2005) J Neurochem. 95(4):919-29 (PubMedId:
- Canals M, Angulo E, Casado V, Canela EI, Mallol J, Vinals F, Staines W, Tinner B, Hillion J, Agnati L, Fuxe K, Ferre S, Lluis C, Franco R. Molecular mechanisms involved in the adenosine A and A receptor-induced
neuronal differentiation in neuroblastoma cells and striatal primarycultures. (2005) J Neurochem. 92(2):337-48. (PubMedId: 15663481
- Saura J, Angulo E, Ejarque A, Casado V, Tusell JM, Moratalla R, Chen JF, Schwarzschild MA, Lluis C, Franco R, Serratosa J. Adenosine A2A receptor stimulation potentiates nitric oxide release by
activated microglia. (2005) J Neurochem. 95(4):919-29. Epub 2005 Aug 10. (PubMedId: 16092928
- Pacheco R, Martinez-Navio JM, Lejeune M, Climent N, Oliva H, Gatell JM, Gallart T, Mallol J, Lluis C, Franco R. CD26, adenosine deaminase, and adenosine receptors mediate costimulatory
signals in the immunological synapse. (2005) Proc Natl Acad Sci U S A. 102(27):9583-8. Epub 2005 Jun 27. (PubMedId: 15983379
- Franco R, Casado V, Mallol J, Ferre S, Fuxe K, Cortes A, Ciruela F, Lluis C, Canela EI. Dimer-based model for heptaspanning membrane receptors. (2005) Trends Biochem Sci. 30(7):360-6. (PubMedId: 15951182
- Ciruela F, Burgueno J, Casado V, Canals M, Marcellino D, Goldberg SR, Bader M, Fuxe K, Agnati LF, Lluis C, Franco R, Ferre S, Woods AS. Combining mass spectrometry and pull-down techniques for the study of
receptor heteromerization. Direct epitope-epitope electrostaticinteractions between adenosine A2A and dopamine D2 receptors. (2004) Anal Chem. 76(18):5354-63. (PubMedId: 15362892
- Agnati LF, Ferre S, Leo G, Lluis C, Canela EI, Franco R, Fuxe K. On the molecular basis of the receptor mosaic hypothesis of the engram. (2004) Cell Mol Neurobiol. 24(4):501-16. (PubMedId: 15233375
- Burgueno J, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. Mutual regulation between metabotropic glutamate type 1alpha receptor and
caveolin proteins: from traffick to constitutive activity. (2004) Exp Cell Res. 300(1):23-34. (PubMedId: 15383311
- Pacheco R, Ciruela F, Casado V, Mallol J, Gallart T, Lluis C, Franco R. Group I metabotropic glutamate receptors mediate a dual role of glutamate
in T cell activation. (2004) J Biol Chem. 279(32):33352-8. Epub 2004 Jun 7. (PubMedId: 15184389
- Canals M, Burgueno J, Marcellino D, Cabello N, Canela EI, Mallol J, Agnati L, Ferre S, Bouvier M, Fuxe K, Ciruela F, Lluis C, Franco R. Homodimerization of adenosine A2A receptors: qualitative and quantitative
assessment by fluorescence and bioluminescence energy transfer. (2004) J Neurochem. 88(3):726-34. (PubMedId: 14720222
- Angulo E, Noe V, Casado V, Mallol J, Gomez-Isla T, Lluis C, Ferrer I, Ciudad CJ, Franco R. Up-regulation of the Kv3.4 potassium channel subunit in early stages of
Alzheimer’s disease. (2004) J Neurochem. 91(3):547-57. (PubMedId: 15485486
- Quarta D, Borycz J, Solinas M, Patkar K, Hockemeyer J, Ciruela F, Lluis C, Franco R, Woods AS, Goldberg SR, Ferre S. Adenosine receptor-mediated modulation of dopamine release in the nucleus
accumbens depends on glutamate neurotransmission and N-methyl-D-aspartatereceptor stimulation. (2004) J Neurochem. 91(4):873-80. (PubMedId: 15525341
- Duflot S, Riera B, Fernandez-Veledo S, Casado V, Norman RI, Casado FJ, Lluis C, Franco R, Pastor-Anglada M. ATP-sensitive K(+) channels regulate the concentrative adenosine
transporter CNT2 following activation by A(1) adenosine receptors. (2004) Mol Cell Biol. 24(7):2710-9. (PubMedId: 15024061
- Ferre S, Ciruela F, Canals M, Marcellino D, Burgueno J, Casado V, Hillion J, Torvinen M, Fanelli F, Benedetti Pd P, Goldberg SR, Bouvier M, Fuxe K, Agnati LF, Lluis C, Franco R, Woods A. Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for
neuro-psychiatric disorders. (2004) Parkinsonism Relat Disord. 10(5):265-71. (PubMedId: 15196504
- Angulo E, Casado V, Mallol J, Canela EI, Vinals F, Ferrer I, Lluis C, Franco R. A1 adenosine receptors accumulate in neurodegenerative structures in
Alzheimer disease and mediate both amyloid precursor protein processingand tau phosphorylation and translocation. (2003) Brain Pathol. 13(4):440-51. (PubMedId: 14655750
- Escriche M, Burgueno J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluis C, Franco R.. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. (2003) Exp Cell Res. 15;285(1):72-90. (PubMedId: 12681288
- Burgueno J, Blake DJ, Benson MA, Tinsley CL, Esapa CT, Canela EI, Penela P, Mallol J, Mayor F Jr, Lluis C, Franco R, Ciruela F. The adenosine A2A receptor interacts with the actin-binding protein
alpha-actinin. (2003) J Biol Chem. 278(39):37545-52. Epub 2003 Jul 1. (PubMedId: 12837758
- Canals M, Marcellino D, Fanelli F, Ciruela F, de Benedetti P, Goldberg SR, Neve K, Fuxe K, Agnati LF, Woods AS, Ferre S, Lluis C, Bouvier M, Franco R. Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative
and quantitative assessment by fluorescence and bioluminescence energytransfer. (2003) J Biol Chem. 278(47):46741-9. Epub 2003 Aug 21. (PubMedId: 12933819
- Burgueno J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. Metabotropic glutamate type 1alpha receptor localizes in low-density
caveolin-rich plasma membrane fractions. (2003) J Neurochem. 86(4):785-91. (PubMedId: 12887677
- Agnati LF, Ferre S, Lluis C, Franco R, Fuxe K. Molecular mechanisms and therapeutical implications of intramembrane
receptor/receptor interactions among heptahelical receptors with examplesfrom the striatopallidal GABA neurons. (2003) Pharmacol Rev. 55(3):509-50. Epub 2003 Jul 17. (PubMedId: 12869660
- Franco R, Canals M, Marcellino D, Ferre S, Agnati L, Mallol J, Casado V, Ciruela F, Fuxe K, Lluis C, Canela EI. Regulation of heptaspanning-membrane-receptor function by dimerization and
clustering. (2003) Trends Biochem Sci. 28(5):238-43. (PubMedId: 12765835
- Hillion J, Canals M, Torvinen M, Casado V, Scott R, Terasmaa A, Hansson A, Watson S, Olah ME, Mallol J, Canela EI, Zoli M, Agnati LF, Ibanez CF, Lluis C, Franco R, Ferre S, Fuxe K.. Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors. (2002) J Biol Chem. 277(20):18091-7 (PubMedId: 11872740
- Ferre S, Karcz-Kubicha M, Hope BT, Popoli P, Burgueno J, Gutierrez MA, Casado V, Fuxe K, Goldberg SR, Lluis C, Franco R, Ciruela F.. Ferre S, Karcz-Kubicha M, Hope BT, Popoli P, Burgueno J, Gutierrez MA, Casado V, Fuxe K, Goldberg SR, Lluis C, Franco R, Ciruela F. (2002) Proc Natl Acad Sci U S A. 99(18):11940-5. (PubMedId: 12189203
- Herrera C, Morimoto C, Blanco J, Mallol J, Arenzana F, Lluis C, Franco R.. Comodulation of CXCR4 and CD26 in human lymphocytes. (2001) J Biol Chem. 276(22):19532-9 (PubMedId: 11278278
- Blanco J, Valenzuela A, Herrera C, Lluis C, Hovanessian AG, Franco R.. The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression. (2000) FEBS Lett. 477(1-2):123-8. (PubMedId: 10899322
- Sarrio S, Casado V, Escriche M, Ciruela F, Mallol J, Canela EI, Lluis C, Franco R.. The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane. (2000) Mol Cell Biol. 20(14):5164-74. (PubMedId: 10866672
- Gines S, Hillion J, Torvinen M, Le Crom S, Casado V, Canela EI, Rondin S, Lew JY, Watson S, Zoli M, Agnati LF, Verniera P, Lluis C, Ferre S, Fuxe K, Franco R.. Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes. (2000) Proc Natl Acad Sci U S A. 97(15):8606-11. (PubMedId: 10890919
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