| URL: | http://www.ub.edu/tam/ |
Personal Adscrit |
| Investigador/a Principal | Francesc Villarroya Gombau |
| Personal de plantilla | Marta Giralt Oms, Roser Iglesias Coll, Teresa Mampel Astals, Octavi Viñas Folch |
| Col.laboradors | Rubén Cereijo Tellez, Julieta Díaz Delfín, José Miguel Gallego Escuredo, Aleix Gavaldá Navarro, Albert Giralt Coll, Elayne Hondares Viera, Isis Navarro Reflero, Anna Planavila Porta, Francesc Ribas Aulinas, Joan Villarroya Terrade |
Línies de recerca |
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Publicacions relevantsLlista completa |
- Hondares E, Mora O, Yubero P, de la Concepcion MR, Iglesias R, Giralt M, Villarroya F. Thiazolidinediones and rexinoids induce PGC-1{alpha} gene transcription.
An auto-regulatory loop controls PGC-1{alpha} expression in adipocytes viaPPAR{gamma} co-activation. (2006) Endocrinology. . (PubMedId: 16513826
- Zamora, M.; Ortega, J.A.; Alaña, L.; Viñas, O.; Mampel, T. Apoptotic and anti-proliferative effects of all-trans retinoic acid. Adenine nucleotide translocase sensitizes HeLa cells to all-trans retinoic acid.
(2006) Exp Cell Res. 312 (10): 1813-1819 (PubMedId:
- Guallar JP, Vila MR, Lopez-Gallardo E, Solano A, Domingo JC, Gamez J, Pineda M, Capablo JL, Domingo P, Andreu AL, Montoya J, Giralt M, Villarroya F. Altered expression of master regulatory genes of adipogenesis in lipomas
from patients bearing tRNA(Lys) point mutations in mitochondrial DNA. (2006) Mol Genet Metab. . (PubMedId: 16603396
- Rodriguez de la Concepcion ML, Yubero P, Domingo JC, Iglesias R, Domingo P, Villarroya F, Giralt M. Reverse transcriptase inhibitors alter uncoupling protein-1 and
mitochondrial biogenesis in brown adipocytes. (2005) Antivir Ther. 10(4):515-26. (PubMedId: 16038477
- Miro O, Villarroya J, Garrabou G, Lopez S, Rodriguez de la Concepcion M, Pedrol E, Martinez E, Giralt M, Gatell JM, Cardellach F, Casademont J, Villarroya F. In vivo effects of highly active antiretroviral therapies containing the
protease inhibitor nelfinavir on mitochondrially driven apoptosis. (2005) Antivir Ther. 10(8):945-51. (PubMedId: 16430200
- Solanes G, Pedraza N, Calvo V, Vidal-Puig A, Lowell BB, Villarroya F. Thyroid hormones directly activate the expression of the human and mouse
uncoupling protein-3 genes through a thyroid response element in theproximal promoter region. (2005) Biochem J. 386(Pt 3):505-13. (PubMedId: 15496137
- Carmona MC, Hondares E, Rodriguez de la Concepcion ML, Rodriguez-Sureda V, Peinado-Onsurbe J, Poli V, Iglesias R, Villarroya F, Giralt M. Defective thermoregulation, impaired lipid metabolism, but preserved
adrenergic induction of gene expression in brown fat of mice lackingC/EBPbeta. (2005) Biochem J. 389(Pt 1):47-56. (PubMedId: 15762841
- Rodriguez de la Concepcion ML, Yubero P, Iglesias R, Giralt M, Villarroya F. Lithium inhibits brown adipocyte differentiation. (2005) FEBS Lett. 579(7):1670-4. (PubMedId: 15757659
- Villarroya F, Domingo P, Giralt M. Lipodystrophy associated with highly active anti-retroviral therapy for
HIV infection: the adipocyte as a target of anti-retroviral-inducedmitochondrial toxicity. (2005) Trends Pharmacol Sci. 26(2):88-93. (PubMedId: 15681026
- Rodriguez de la Concepcion ML, Domingo JC, Domingo P, Giralt M, Villarroya F. Uncoupling protein 1 gene expression implicates brown adipocytes in highly
active antiretroviral therapy-associated lipomatosis. (2004) AIDS. 18(6):959-60. (PubMedId: 15060448
- Villarroya F, Iglesias R, Giralt M. Retinoids and retinoid receptors in the control of energy balance: novel
pharmacological strategies in obesity and diabetes. (2004) Curr Med Chem. 11(6):795-805. (PubMedId: 15032732
- Yubero P, Hondares E, Carmona MC, Rossell M, Gonzalez FJ, Iglesias R, Giralt M, Villarroya F. The developmental regulation of peroxisome proliferator-activated
receptor-gamma coactivator-1alpha expression in the liver is partiallydissociated from the control of gluconeogenesis and lipid catabolism. (2004) Endocrinology. 145(9):4268-77. (PubMedId: 15178647
- Zamora, M.;Granell, M.; Mampel, T.; Viñas, O. Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells (2004) FEBS Lett. 563: 155-160 (PubMedId:
- Zamora, M.; Meroño, C.; Viñas, O.; Mampel, T. Recruitment of NF-kB into Mitochondria Is Involved in Adenine Nucleotide Translocase 1 (ANT1)-induced Apoptosis. (2004) J Biol Chem. 279: 38415-38423 (PubMedId:
- Dejean L, Camara Y, Sibille B, Solanes G, Villarroya F. Uncoupling protein-3 sensitizes cells to mitochondrial-dependent stimulus
of apoptosis. (2004) J Cell Physiol. 201(2):294-304. (PubMedId: 15334664
- Notario, B.; Manchado, C.; Zamora, M.; Mampel, T.; Viñas, O. Assessment of membrane-bound mitochondrial adenine nucleotide translocase topography by experimental antibodies (2003) Biochemistry. 42: 820-828 (PubMedId:
- Solanes G, Pedraza N, Iglesias R, Giralt M, Villarroya F. Functional relationship between MyoD and peroxisome proliferator-activated
receptor-dependent regulatory pathways in the control of the humanuncoupling protein-3 gene transcription. (2003) Mol Endocrinol. 17(10):1944-58. (PubMedId: 12843208
- Notario, B.; Zamora, M.; Manchado, C.; Viñas, O.; Mampel, T. All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition (2003) Mol Pharmacol. 63: 224-231 (PubMedId:
- Schluter A, Barbera MJ, Iglesias R, Giralt M, Villarroya F. Phytanic acid, a novel activator of uncoupling protein-1 gene
transcription and brown adipocyte differentiation. (2002) Biochem J. 362(Pt 1):61-9. (PubMedId: 11829740
- Villena JA, Carmona MC, Rodriguez de la Concepcion M, Rossmeisl M, Vinas O, Mampel T, Iglesias R, Giralt M, Villarroya F. Mitochondrial biogenesis in brown adipose tissue is associated with
differential expression of transcription regulatory factors. (2002) Cell Mol Life Sci. 59(11):1934-44. (PubMedId: 12530524
- Schluter A, Giralt M, Iglesias R, Villarroya F. Phytanic acid, but not pristanic acid, mediates the positive effects of
phytol derivatives on brown adipocyte differentiation. (2002) FEBS Lett. 517(1-3):83-6. (PubMedId: 12062414
- Schluter A, Yubero P, Iglesias R, Giralt M, Villarroya F. The chlorophyll-derived metabolite phytanic acid induces white adipocyte
differentiation. (2002) Int J Obes Relat Metab Disord. 26(9):1277-80. (PubMedId: 12187408
- Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F, Giralt M. Mitochondrial biogenesis and thyroid status maturation in brown fat
require CCAAT/enhancer-binding protein alpha. (2002) J Biol Chem. 277(24):21489-98. Epub 2002 Apr 8. (PubMedId: 11940593
- Manchado C, Orus J, Villarroya F, Roig E, Heras M, Giralt M, Iglesias R, Sanz G, Mampel T, Vinas O. Epitope mapping of mitochondrial adenine nucleotide translocase-1 in
idiopathic dilated cardiomyopathy. (2002) J Mol Cell Cardiol. 34(5):571-82. (PubMedId: 12056860
- Garcia-Martinez C, Sibille B, Solanes G, Darimont C, Mace K, Villarroya F, Gomez-Foix AM. Overexpression of UCP3 in cultured human muscle lowers mitochondrial
membrane potential, raises ATP/ADP ratio, and favors fatty acid vs.glucose oxidation. (2001) FASEB J. 15(11):2033-5. (PubMedId: 11511517
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