Personal Adscrit |
| Investigador/a Principal | Anna Maria Gómez Foix |
| Personal de plantilla | Celia Garcia Martinez |
| Personal de support | Anna Orozco Garcia |
| Col.laboradors | Maria Guitart De la rosa, Marta Montori Grau, Emma Mormeneo Beltran |
Línies de recerca |
-Estudi de cèl-lules del múscul humà en cultiu primari, com a model de procés normal i patològic.
-Estudi de la interrelació entre el metabolisme lipídic i el de la glucosa en cèl-lules del múscul humà en cultiu primari i de la seva implicació en la diabetis.
-Desenvolupament de nous vectors adenovirals amb expressió regulable per lliurament in vivo al teixit muscular. |
Publicacions relevantsLlista completa |
- Ferrer-Martinez A, Marotta M, Turini M, Mace K, Gomez-Foix AM. Effect of sucrose and saturated-fat diets on mRNA levels of genes limiting
muscle fatty acid and glucose supply in rats. (2006) Lipids. 41(1):55-62. (PubMedId: 16555472
- Garcia-Martinez C, Marotta M, Moore-Carrasco R, Guitart M, Camps M, Busquets S, Montell E, Gomez-Foix AM. Impact on fatty acid metabolism and differential localization of FATP1 and
FAT/CD36 proteins delivered in cultured human muscle cells. (2005) Am J Physiol Cell Physiol. 288(6):C1264-72. (PubMedId: 15897321
- Ferrer-Martinez A, Marotta M, Baldan A, Haro D, Gomez-Foix AM. Chicken ovalbumin upstream promoter-transcription factor I represses the
transcriptional activity of the human muscle glycogen phosphorylasepromoter in C2C12 cells. (2004) Biochim Biophys Acta. 1678(2-3):157-62. (PubMedId: 15157742
- Marotta M, Bragos R, Gomez-Foix AM. Design and performance of an electrical stimulator for long-term
contraction of cultured muscle cells. (2004) Biotechniques. 36(1):68-73. (PubMedId: 14740487
- Ferrer-Martinez A, Riera A, Jimenez-Chillaron JC, Herrero P, Moreno F, Gomez-Foix AM. A glucose response element from the S. cerevisiae hexose transporter HXT1
gene is sensitive to glucose in human fibroblasts. (2004) J Mol Biol. 338(4):657-67. (PubMedId: 15099735
- Marotta M, Ferrer-Martnez A, Parnau J, Turini M, Mace K, Gomez Foix AM. Fiber type- and fatty acid composition-dependent effects of high-fat diets
on rat muscle triacylglyceride and fatty acid transporter protein-1content. (2004) Metabolism. 53(8):1032-6. (PubMedId: 15281014
- Ferrer-Martinez A, Garcia-Martinez C, Gomez-Foix AM. Use of adenoviral vectors with a minimal cytomegalovirus promoter. (2003) Biotechniques. 34(3):600-2. (PubMedId: 12661164
- Lerin C, Montell E, Nolasco T, Clark C, Brady MJ, Newgard CB, Gomez-Foix AM. Regulation and function of the muscle glycogen-targeting subunit of
protein phosphatase 1 (GM) in human muscle cells depends on theCOOH-terminal region and glycogen content. (2003) Diabetes. 52(9):2221-6. (PubMedId: 12941760
- Ferrer-Martinez A, Gomez-Foix AM. Laser scanning cytometry to quantify gene transfer efficiency and
transcriptional activity of EGFP constructs. (2002) Biotechniques. 32(1):62, 64-6. (PubMedId: 11808700
- Montell E, Lerin C, Newgard CB, Gomez-Foix AM. Effects of modulation of glycerol kinase expression on lipid and
carbohydrate metabolism in human muscle cells. (2002) J Biol Chem. 277(4):2682-6. Epub 2001 Nov 19. (PubMedId: 11714702
- Jimenez-Chillaron JC, Telemaque-Potts S, Gomez-Valades AG, Anderson P, Newgard CB, Gomez-Foix AM. Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats
improves insulin-sensitive glucose uptake. (2002) Metabolism. 51(1):121-6. (PubMedId: 11782883
- Montell E, Turini M, Marotta M, Roberts M, Noe V, Ciudad CJ, Mace K, Gomez-Foix AM. DAG accumulation from saturated fatty acids desensitizes insulin
stimulation of glucose uptake in muscle cells. (2001) Am J Physiol Endocrinol Metab. 280(2):E229-37. (PubMedId: 11158925
- Garcia-Martinez C, Sibille B, Solanes G, Darimont C, Mace K, Villarroya F, Gomez-Foix AM. Overexpression of UCP3 in cultured human muscle lowers mitochondrial
membrane potential, raises ATP/ADP ratio, and favors fatty acid vs.glucose oxidation. (2001) FASEB J. 15(11):2033-5. (PubMedId: 11511517
- Lerin C, Montell E, Berman HK, Newgard CB, Gomez-Foix AM. Overexpression of protein targeting to glycogen in cultured human muscle
cells stimulates glycogen synthesis independent of glycogen and glucose6-phosphate levels. (2000) J Biol Chem. 275(51):39991-5. (PubMedId: 10998419
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