RELEVANT FINDINGS (NEUROBIOLOGY AND IMMUNOLOGY)
PROTEIN-PROTEIN INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM
Discovery
of dopamine-adenosine receptor-receptor
heteromerization. Novel targets for Parkinson's disease
Discovery
of glutamate-adenosine receptor-receptor
heteromerization. Novel targets for chronic neurological diseases
PROTEIN-PROTEIN INTERACTIONS IN THE IMMUNE SYSTEM RECEPTOR BIOCHEMISTRY AND CELL BIOLOGY Discovery of cell surface adenosine deaminase in neurons
Demonstration of
the interaction betwen the heat shock cogante protein
hsc73 and the A1 adenosine receptor (G protein-coupled receptor)Discovery
of A1 adenosine receptors
as ecto-ADA binding protein Discovery
of ecto-adenosine deaminase (ecto-ADA) in
lymphocytes and other cell types: Role of ecto-ADA in
signallingDemonstration
of a costimulatory role of ecto-ADA in lymphocytes
Characterization
of A2B adenosine receptors in human and
murine blood cellsDemonstration of A2 adenosine receptors
as a lymphocyte surface protein interacting with ecto-ADAIdentification of functional modules: chemokine receptor (CXCR4)-CD26-Adenosine deaminase in lymphocytes: Role in HIV infection Discovery
of a molecular mechanism by which HIV alters
T cell activation in cells from AIDS patients
Demonstration
of ligand-induced clusterization, phosphorylation
and internalization of membrane receptorsDiscovery of a direct interaction between G protein coupled receptors and caveolin: Role in receptor traffic and endocytic differential sorting.Development
of a cluster -arranged model for kinetics
of ligand binding to G protein-coupled receptors